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Long-Term Changes in Ventricular Function in Recreational Marathon Runners.

Michael Johannes Schindler1,2, Julia Schoenfeld2,3, Amelie Trommler2

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Summary
This summary is machine-generated.

Repetitive marathon running did not cause long-term right ventricle damage, despite temporary troponin T increases. Left ventricle function changes remained within normal limits over 10 years in male endurance athletes.

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Area of Science:

  • Cardiology
  • Sports Medicine
  • Exercise Physiology

Background:

  • Long-term effects of strenuous exercise on cardiac function, particularly the right ventricle, are not fully understood.
  • Plasma troponin levels can increase after endurance events, but their long-term implications remain unclear.

Purpose of the Study:

  • To examine the association between marathon-induced troponin T elevation and right ventricular remodeling after a decade of consistent endurance training.
  • To assess long-term changes in right and left ventricular function in male marathon runners.

Main Methods:

  • A longitudinal observational cohort study (Pro-MagIC) followed 152 male marathon runners for 10 years.
  • Cardiac biomarkers and 3D echocardiography were measured at multiple time points: prerace, immediately postrace, and at 1, 3 days, and 10 years postrace.
  • Analysis focused on right ventricular ejection fraction, left ventricular ejection fraction, and left ventricular filling pressures.

Main Results:

  • Right ventricular ejection fraction transiently decreased post-marathon but recovered to baseline levels by 3 days and remained stable at 10-year follow-up.
  • No association was found between acute exercise-induced troponin T increase and long-term right or left ventricular ejection fraction.
  • Left ventricular ejection fraction and diastolic function showed changes but remained within normal physiological limits at 10-year follow-up.

Conclusions:

  • Repetitive strenuous exercise and marathon competition do not appear to cause long-term right ventricular dysfunction in recreational male athletes.
  • While acute cardiac biomarker elevations occur, they do not predict long-term adverse cardiac remodeling in this population.
  • Endurance athletes maintain cardiac function within normal limits despite significant training loads over a decade.