Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

What is Gene Expression?

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Satellite DNA sequence dictates pericentromere heterochromatin formation and function.

Science advances·2026

Same author

A data-driven framework reconstructs the molecular continuum of human MASLD progression.

Nature metabolism·2026

Same author

Author Correction: A generalizable approach for programming protease-responsive conformationally inhibited artificial transcriptional factors.

Nature communications·2026

Same author

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.

Nature communications·2026

Same author

What influences whether researchers adhere to healthcare reporting guidelines successfully? A thematic synthesis.

Research integrity and peer review·2026

Same author

Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection.

Nature medicine·2026

Search research articles

Related Experiment Video

Updated: Apr 13, 2026

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Published on: May 31, 2012

Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration.

Pedro Madrigal¹, Anil S Thanki¹, Silvie Fexova¹

¹European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, United Kingdom.

Nucleic Acids Research

|December 10, 2025

Summary

Expression Atlas is a comprehensive gene and protein expression knowledgebase. It now includes over 4500 studies, single-cell RNA-seq data, and new analysis tools, enhancing biological discovery.

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Related Experiment Videos

Last Updated: Apr 13, 2026

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Published on: May 31, 2012

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Area of Science:

Bioinformatics
Genomics
Proteomics

Background:

Expression Atlas is a key resource from EMBL-EBI for gene and protein expression data.
It covers multiple species, tissues, cell types, and conditions.

Purpose of the Study:

To detail the recent expansion and enhanced functionality of the Expression Atlas.
To highlight new data types, analysis modules, and integration capabilities.

Main Methods:

Data integration from >4500 studies across 67 species.
Inclusion of hundreds of single-cell RNA-seq experiments from 21 species.
Development of a new marker gene analysis module for bulk baseline experiments.

Main Results:

Substantial expansion in content and functionality.
Increased proteomics coverage and updated Genotype-Tissue Expression (GTEx) profiles.
Integration of community datasets and enhanced reproducibility through workflow updates.

Conclusions:

Expression Atlas is a significantly enhanced, FAIR community-driven resource.
It supports both fundamental and translational research through expanded data and tools.
Future developments focus on modernizing pipelines and AI-ready data formats.