Bridging Brain and Machine: A Neurocognitive Framework for Early Alzheimer's Detection Through Hierarchical Speech...

Alzheimer's disease progressively disrupts temporal-frontal language networks, manifesting through degraded speech production detectable years before clinical dementia diagnosis. Traditional automated detection systems rely on handcrafted acoustic features, including mel-frequency cepstral coefficients, that may discard diagnostically relevant temporal dynamics through fixed spectral transformations. Drawing inspiration from cognitive neuroscience models of hierarchical speech processing, we propose the neuro residual acoustic learning framework, an end-to-end system operating directly on raw waveforms while incorporating architectural principles mirroring biological auditory pathways. The framework implements acoustic-symbolic transformation bridging continuous signals and discrete phonetic-acoustic categories analogous to primary auditory cortex processing, hierarchical temporal encoding through residual blocks with dilated convolutions capturing multi-scale patterns across phoneme to utterance timescales, and squeeze-and-excitation attention mechanisms modeling prefrontal modulation of temporal representations. Evaluation on NCMMSC2021 Mandarin speech demonstrates 86.55% accuracy on extended utterances and 81.35% on brief segments, surpassing contemporary methods, including multimodal architectures and large language model hybrids, by 2.88% and 2.43% respectively. Cross-linguistic validation on INTERSPEECH2020 ADReSS English speech achieves 70.83% accuracy, exceeding baselines by 2.08%. Confusion matrix analysis reveals 93.3% healthy control recall and asymmetric Alzheimer's disease versus mild cognitive impairment misclassification patterns consistent with prodromal acoustic biomarkers.