Skin Microbiota: A Novel Target for Promoting Burn Wound Healing

Human skin is the outermost complex ecosystem that hosts numerous microbial communities. The reciprocal communication between these microbial inhabitants and host cells plays pivotal roles in maintaining skin homeostasis. While current research primarily focuses on the functions of skin microbiota in chronic wounds, the mechanisms by which skin microbiota affect acute wounds such as burn wounds need further exploration. Until recently, an increasing body of evidence has proven the indispensable role of skin microbiota in burn wound healing, suggesting that targeting skin microbiota maybe a highly promising therapeutic approach in treating burns. This review aims to summarize current research findings, with a focus on discussing the dynamic alterations of skin microbiota following burns and its profound impact on the wound healing process. Additionally, we delve into strategies for maintaining microbial homeostasis to facilitate effective healing of burn wounds, offering new perspectives for research and practice in related fields.