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Four New Alkaloid Heterodimers From Scolopendra subspinipes mutilans
Bin-Yuan Hu1,2, Cong Fu2, Wu-Mei Sun1,2
1School of Chinese Materia Medica &Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan International Joint Laboratory for Exploration and Utilization of Aromatic Chinese Medicinal Materials in Agriculture, Yunnan University of Chinese Medicine, Kunming, People's Republic of China.
None:
Three rare pyrazine-containing alkaloid heterodimers scosubspiloids A-C (1-3) and one new spiro-indole heterodimer scosubspiloid D (4), along with seven known alkaloids (5-11) were isolated from Scolopendra subspinipes mutilans. Spectroscopic methods and ECD calculations were used to identify their structures. Biologically, 1-3 could significantly inhibit the proliferation of MDA-MB-231 cells at 20 µM. The investigation provided experimental evidences to support the traditional use of S. subspinipes mutilans in treating cancer, and revealed new structure type compounds in the medicinal animal.
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