Supplements for bone health
Tiago Donizeti Bertolacini da Silva1,2, Gabriela Mazzarolo Marcondes Vieira1, Layana Tyara Sandes Fraga1
1Departamento de Medicina, Divisão de Endocrinologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Archives of Endocrinology and Metabolism
|December 10, 2025
Summary
This review examines key micronutrients for bone health, including calcium and vitamin D. Evidence supports their role in reducing bone loss, but supplementation benefits vary for other nutrients.
Area of Science:
- Nutrition Science
- Bone Metabolism
- Public Health
Background:
- Bone health is multifactorial, influenced by genetics, hormones, and environment.
- Nutrition is a critical factor in maintaining skeletal integrity throughout life.
Purpose of the Study:
- To review the role of essential micronutrients (calcium, vitamin D, K, magnesium, phosphorus) in bone health.
- To assess current micronutrient intake in Brazil and discuss supplementation risks.
Main Methods:
- Literature review of scientific evidence on micronutrients and bone health.
- Analysis of nutritional status and supplementation guidelines.
Main Results:
- Calcium and vitamin D show benefits in reducing bone loss, especially in deficient populations.
- Evidence for vitamin K, magnesium, and phosphorus supplementation is less consistent or context-specific.
- Potential risks of excessive supplementation include cardiovascular issues and metabolic disturbances.
Conclusions:
- An individualized, evidence-based approach is recommended for optimizing bone health.
- Micronutrient supplementation should be carefully considered due to potential risks and variable efficacy.
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