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The Childhood Cancer Data Initiative (CCDI) offers tools and resources for accessing and analyzing diverse pediatric cancer data. This facilitates research to improve understanding, treatment, and outcomes for childhood cancers.

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Area of Science:

  • Pediatric Oncology
  • Cancer Genomics
  • Data Science in Medicine

Background:

  • Advancing understanding of childhood, adolescent, and young adult cancers requires comprehensive data sharing.
  • The National Cancer Institute's Childhood Cancer Data Initiative (CCDI) addresses this need by providing access to a vast repository of diverse cancer data.

Purpose of the Study:

  • To outline the process of finding, requesting, accessing, downloading, and analyzing data within the CCDI Data Ecosystem.
  • To highlight the role of the CCDI Hub Explore Dashboard and Childhood Cancer Clinical Data Commons (C3DC) in accelerating pediatric cancer research.

Main Methods:

  • Utilizing cohort-based analysis supported by CCDI resources.
  • Employing standardized data models for study, participant, sample, diagnosis, and treatment data, updated collaboratively.
  • Leveraging a drafted Pediatric Cancer Core common data elements list for standardized research references.

Main Results:

  • The CCDI Hub serves as the central access point for CCDI data, tools, and applications.
  • The C3DC offers harmonized, participant-level clinical data, while the CCDI Hub Explore Dashboard catalogs file-level data.
  • Users can search, download data manifests, and build cohorts using harmonized, de-identified participant data.

Conclusions:

  • CCDI emphasizes data accessibility and interoperability to foster pediatric cancer research discovery.
  • CCDI resources and data support data-driven insights and enhance collaboration within the pediatric cancer research community.