Building Pediatric Cancer Cohorts and Accessing Data Using Childhood Cancer Data Initiative Tools

Area of Science:

• Pediatric Oncology
• Cancer Genomics
• Data Science in Medicine

Background:

• Advancing understanding of childhood, adolescent, and young adult cancers requires comprehensive data sharing.
• The National Cancer Institute's Childhood Cancer Data Initiative (CCDI) addresses this need by providing access to a vast repository of diverse cancer data.

Purpose of the Study:

• To outline the process of finding, requesting, accessing, downloading, and analyzing data within the CCDI Data Ecosystem.
• To highlight the role of the CCDI Hub Explore Dashboard and Childhood Cancer Clinical Data Commons (C3DC) in accelerating pediatric cancer research.

Main Methods:

• Utilizing cohort-based analysis supported by CCDI resources.
• Employing standardized data models for study, participant, sample, diagnosis, and treatment data, updated collaboratively.
• Leveraging a drafted Pediatric Cancer Core common data elements list for standardized research references.

Main Results:

• The CCDI Hub serves as the central access point for CCDI data, tools, and applications.
• The C3DC offers harmonized, participant-level clinical data, while the CCDI Hub Explore Dashboard catalogs file-level data.
• Users can search, download data manifests, and build cohorts using harmonized, de-identified participant data.

Conclusions:

• CCDI emphasizes data accessibility and interoperability to foster pediatric cancer research discovery.
• CCDI resources and data support data-driven insights and enhance collaboration within the pediatric cancer research community.