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Published on: August 23, 2018
Discovery and evaluation of FM-8007: A potent and persistent biphenyl bistrifluoroethyl sulfide acaricide
Dongdong Liu1, Hongyan Pei2, Haiping Tian2
1National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang 110142, China; Department of Chemical and Material Engineering, Lyuliang University, Lvliang 033001, China; School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, Liaoning, China.
Abstract:
The development of novel acaricides is crucial to combating the growing resistance of phytophagous mites to traditional pesticides. This study presents FM-8007, a potent biphenyl bistrifluoroethyl sulfide acaricide, designed through systematic structural optimization. FM-8007 exhibits broad-spectrum efficacy against Tetranychus cinnabarinus, with LC50 values of 1.1 mg/L for adults, 0.25 mg/L for larvae, and 0.85 mg/L for eggs, comparable to the commercial standard cyetpyrafen. Field trials demonstrated its lasting effectiveness in controlling Panonychus citri, maintaining ≥95 % efficacy for over 30 days. The structure-activity relationship (SAR) analysis identified key features essential for high efficacy, including an intact biphenyl scaffold with dual CF3CH2S- groups and specific electron-withdrawing substituents. FM-8007 provides a promising new tool for integrated pest management (IPM) strategies.
