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Published on: March 1, 2024
Polychondritis and Arthritis in a Patient with Coexisting Alkaptonuria and Psoriasis Vulgaris
Kensei Shono1, Eiko Kawakami1, Serina Koto1
1Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Abstract:
Alkaptonuria is an organic acid metabolic disorder caused by abnormalities of the tyrosine metabolic pathway. Herein, we report a case of relapsing polychondritis and arthritis in a patient with alkaptonuria and psoriasis vulgaris, respectively. A 53-year-old man, previously diagnosed with alkaptonuria and psoriasis vulgaris, was found to have auricular thickening and tenderness, bilateral bulbar conjunctival injection, and elevated C-reactive protein levels. Ultrasound imaging revealed enthesitis in the bilateral knee joints. A biopsy of the auricular cartilage revealed lymphocytic infiltration. The coexistence of ocular involvement, auricular chondritis, and enthesitis was considered indicative of alkaptonuria complicated by relapsing polychondritis and psoriatic arthritis.
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