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Structural basis of calcium-dependent C1ql1/BAI3 assemblies in synaptic connectivity

Liangyu Liao1,2, Ying Han3,4, Fengfeng Niu1,2

  • 1Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, Shenzhen, Guangdong, China.

Nature Communications
|December 10, 2025
PubMed
Summary

Secreted C1q-like proteins (C1qls) bridge synapses by forming calcium-modulated hexamers. This dynamic assembly of C1ql1 scaffolds BAI3 receptors, crucial for synaptic connectivity and maintenance.

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