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Dental Manifestations and Clinical Implications of Diamond-Blackfan Anemia

Jade Quearney1, Carolyn Kerins1

  • 1Department of Pediatric Dentistry, Texas A&M University, Dallas, Texas, USA.

Journal of Dentistry for Children (Chicago, Ill.)
|December 10, 2025
PubMed

Insights

Diamond-Blackfan anemia is a rare inherited bone marrow failure syndrome affecting red blood cell production. This case report reviews its dental manifestations and challenges for dental practitioners.

Area of Science:

  • Hematology
  • Genetics
  • Rare Diseases

Background:

  • Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome.
  • It is characterized by reduced red blood cell production due to bone marrow dysfunction.
  • DBA affects 5-7 per million live births annually, often diagnosed in infancy but can present later.

Purpose of the Study:

  • To review the existing literature on Diamond-Blackfan anemia.
  • To highlight the dental manifestations and implications of DBA.
  • To inform dental practitioners about challenges in managing DBA patients.

Main Methods:

  • Literature review on Diamond-Blackfan anemia.
  • Analysis of clinical and genetic findings related to DBA.
  • Synthesis of information on dental aspects of DBA.

Main Results:

  • DBA presents with diverse features, including physical characteristics.
  • Limited literature exists on the specific dental manifestations of DBA.
  • Molecular testing aids in adult DBA diagnosis.

Conclusions:

  • Dental practitioners require awareness of DBA's oral implications.
  • Further research is needed to fully understand DBA's dental impact.
  • Improved understanding can enhance dental care for DBA patients.

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