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Updated: Jan 9, 2026
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A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement
Published on: February 22, 2022
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High-Intensity Interval Training During Cancer Prehabilitation May Improve Cardiorespiratory Fitness: A Meta-Analysis
Simone Cuomo1,2, Paolo Riccardo Brustio2,3, Anna Mulasso1,2
1Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Healthcare (Basel, Switzerland)
|December 11, 2025
Summary
High-intensity interval training (HIIT) prehabilitation significantly improves cardiorespiratory fitness (VO2peak) in cancer patients. This time-efficient strategy enhances functional capacity before treatment, though standardized protocols are needed.
Area of Science:
- Oncology
- Cardiology
- Exercise Physiology
Background:
- Cardiovascular disease is a major cause of mortality in cancer survivors.
- Cardiorespiratory fitness (VO2peak) is crucial for predicting outcomes and complications.
- Prehabilitation offers a window to optimize patient health before cancer treatment.
Purpose of the Study:
- To meta-analyze the effect of high-intensity interval training (HIIT) prehabilitation on VO2peak in cancer patients.
- To determine if HIIT is a time-efficient strategy to improve fitness during prehabilitation.
Main Methods:
- Systematic search of multiple databases (PubMed, Scopus, etc.) up to August 2024.
- Random-effects meta-analysis of 7 studies with 352 participants (mixed cancer types).
- Primary outcome: VO2peak, analyzed using standardized mean differences (SMD).
Main Results:
- HIIT prehabilitation showed a small, statistically significant improvement in VO2peak compared to usual care (SMD = 0.31, p < 0.01).
- Low between-study heterogeneity (I² = 10%) was observed.
- Participants' age ranged from 56-73 years.
Conclusions:
- HIIT-based prehabilitation effectively enhances cardiorespiratory fitness in cancer patients.
- It represents a potentially clinically relevant and time-efficient strategy for pre-treatment optimization.
- Further research with standardized HIIT protocols and intensity verification is warranted due to clinical heterogeneity.
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