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Updated: Jan 9, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Targeting Lactylation for Cancer: Mechanisms, Effects, and Therapeutic Prospects
Dong Chang1, Daolong Li1, Yuxi Sun1
1Biomedical Research Institute, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.
Abstract:
Recent studies reveal that lysine lactylation plays a pivotal and multifaceted role in tumor progression. Here, we provide a systematic overview of the mechanisms underlying lactylation, highlighting its regulation of tumor metabolic reprogramming and immune microenvironment remodeling. We further summarize how lactylation drives malignancy across diverse cancer types and discuss emerging strategies to therapeutically target lactylation in cancer. By integrating current findings, this review offers a comprehensive framework for understanding lactylation in tumor biology and identifies key gaps for future investigation, thereby providing a valuable reference for both basic research and therapeutic development.
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