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Computational Analysis of GAT1 Mutations: Functional Consequences from Molecular Dynamics and Binding Free Energy

Muhammad Yasir1, Jinyoung Park1, Eun-Taek Han2

  • 1Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.

International Journal of Molecular Sciences
|December 11, 2025
PubMed
Summary

GABA transporter 1 (GAT1) mutations impact inhibitory neurotransmission. Computational analysis reveals how specific mutations destabilize GAT1, affecting its function and potentially contributing to neurological disorders.

Keywords:
GAT1GAT1 mutationsepilepsygmx_MMPBSAmolecular dynamics simulationtiagabine

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