Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 9, 2026

Analysis of Oxidative Stress in Zebrafish Embryos

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Chios Mastic Gum Extract Enhances Antioxidant Defense in Zebrafish.

Pelagia Anastasiadou¹, Martina Samiotaki², Theoni Margaritopoulou³

¹Laboratory of Pesticides' Toxicology, Scientific Directorate of Pesticides Control and Phytopharmacy, Benaki Phytopathological Institute, 8 Stefanou Delta Str., 14561 Kifissia, Greece.

International Journal of Molecular Sciences

|December 11, 2025

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tau protein as a regulator of mitochondrial function and dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Dual Role of Cancer Epithelial-Specific TRAF3 in Regulating Breast Cancer Cell Survival and Lymphocyte Activity.

International journal of molecular sciences·2026

Same author

Non-Targeted and Targeted Screening of Organic Contaminants in Honeybees' Death Incidents in Greece: A Story Beyond Pesticides.

Journal of xenobiotics·2026

Same author

Black Soldier Fly Promoted Bioconversion of Tomato Toxic Plant Biomass to Safe, Functional Animal Feed.

Molecules (Basel, Switzerland)·2026

Same author

A Genome-Wide DNA Methylation Survey Reveals Salicylic Acid-Induced Distinct Hypomethylation Linked to Defense Responses Against Biotrophic Pathogens.

International journal of molecular sciences·2026

Same author

Novel Dorsomorphin Derivatives: Molecular Modeling, Synthesis, and Bioactivity Evaluation.

Biomolecules·2026

Chios mastic gum (CMG) enhances antioxidant defenses by boosting key proteins involved in energy metabolism and cellular protection. This study reveals CMG

Area of Science:

Biochemistry
Molecular Biology
Pharmacology

Background:

Chios mastic gum (CMG), a natural resin from *Pistacia lentiscus*, possesses known anti-inflammatory and antioxidant properties.
Existing research suggests CMG's potential in managing health disorders and inhibiting cancer cells.
The precise molecular mechanisms underlying CMG's biological activities require further elucidation.

Purpose of the Study:

To investigate the molecular pathways affected by Chios mastic gum (CMG) using zebrafish embryos as a model.
To identify specific proteins and metabolic processes modulated by CMG treatment.
To understand the cellular mechanisms contributing to CMG's antioxidant effects.

Main Methods:

Zebrafish embryos were exposed to non-toxic concentrations of CMG.

Keywords:

Chios mastic gum catalase copper-zinc superoxide dismutase proteomics thioredoxin-disulfide reductase zebrafish

More Related Videos

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Published on: February 15, 2021

Repeated Blood Collection for Blood Tests in Adult Zebrafish

Repeated Blood Collection for Blood Tests in Adult Zebrafish

Published on: August 30, 2015

Related Experiment Videos

Last Updated: Jan 9, 2026

Analysis of Oxidative Stress in Zebrafish Embryos

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Published on: February 15, 2021

Repeated Blood Collection for Blood Tests in Adult Zebrafish

Repeated Blood Collection for Blood Tests in Adult Zebrafish

Published on: August 30, 2015

Proteomic analysis using LC-HRMS was performed on treated embryos.

Bioinformatic enrichment analysis and hierarchical clustering were employed to identify key pathways and proteins.

Main Results:

CMG treatment significantly modulated pathways including oxidative phosphorylation (OxPhos), the electron transport chain (ETC), and the tricarboxylic acid cycle (TCA).
Proteomic data indicated CMG's role in supporting energy generation and cytoskeletal integrity.
Three major antioxidant proteins—copper-zinc superoxide dismutase, thioredoxin-disulfide reductase, and catalase—were found to be upregulated.

Conclusions:

CMG treatment influences fundamental cellular energy metabolism pathways in zebrafish embryos.
The study confirms CMG's capacity to bolster the antioxidant defense system.
These findings provide molecular insights into the therapeutic potential of Chios mastic gum.