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Updated: Jan 9, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
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Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model

Jiaqin Wu1, Nanjia Dongzhu2, Chengzhou Zhao2

  • 1College of Pharmacy, Qinghai University, Xining 810016, China.

International Journal of Molecular Sciences
|December 11, 2025
PubMed
Abstract

Keywords:
P21/P53/SIRT1 axisapoptosisbidirectional regulationbotanical complexcardiomyocytescellular senescencemulti-targetsenotherapeuticszebrafish model

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