Prevalence Clinical Syndromes and Outcomes of Cow's Milk Allergy in Children: A Four-Year Follow-Up
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View abstract on PubMed
Summary
This summary is machine-generated.Cow's milk allergy (CMA) in infants often presents with gastrointestinal issues. While allergic proctocolitis and food protein-induced enteropathy show good outcomes, IgE-mediated CMA and FPIES require longer management.
Area Of Science
- Pediatrics
- Allergy and Immunology
- Gastroenterology
Background
- Cow's milk allergy (CMA) presents diverse clinical syndromes and symptoms in infants.
- Understanding the prevalence, presentation, and outcomes of CMA subtypes is crucial for infant health.
Purpose Of The Study
- To investigate the prevalence, clinical presentation, and outcomes of different clinical types and subtypes of CMA in infants.
- To analyze the progression and resolution of various CMA manifestations within the first year of life and beyond.
Main Methods
- A mixed retrospective and prospective cohort study followed 93 infants diagnosed with CMA for up to four years.
- Data included clinical manifestations, feeding methods, and outcomes, with follow-up involving oral cow's milk challenges and diagnostic tests like skin prick tests and serum IgE assessments.
Main Results
- Non-IgE-mediated CMA was more prevalent (72%) than IgE-mediated CMA (28%).
- Gastrointestinal symptoms were most common (74%), followed by skin rash (31%).
- Allergic proctocolitis (AP) and Food Protein-induced Enteropathy (FPE) showed high tolerance rates within the first year, unlike Food Protein-Induced Enterocolitis Syndrome (FPIES) and IgE-mediated CMA.
Conclusions
- Allergic proctocolitis (AP) is the predominant CMA subtype, with increased gastrointestinal involvement observed.
- Outcomes are favorable for AP and FPE, but less so for FPIES and IgE-mediated CMA, highlighting the need for tailored management strategies.
- This study enhances understanding of infant CMA syndromes and informs effective management guidelines.
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