Prognostic Value of Resting Energy Expenditure Measured by Indirect Calorimetry in Patients with Cirrhosis Referred
Natalie L Y Ngu1,2, Georgia Knapp1, Helen Vidot1,3
1AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
Background:
Malnutrition is common in cirrhosis but is challenging to identify, grade, and manage during liver transplantation (LT) assessment. The resting energy expenditure informs nutritional needs and can be measured with indirect calorimetry (IC); however, it is not routinely used in this context. We aimed to assess the prognostic value of the measured resting energy expenditure (mREE) and its associations in patients with cirrhosis referred for LT assessment.
Methods:
We performed a single-center, retrospective cohort study of adult patients with cirrhosis who underwent IC between 2002 and 2019 at a statewide LT center. The predicted REE (pREE) was estimated using the Harris-Benedict equation. Patients were classified as normo-, hypo-, and hypermetabolic based on the difference between the mREE and pREE. Malnutrition was determined prospectively using the Subjective Global Assessment. The primary outcome was LT-free survival.
Results:
A total 203 patients were recruited (74% male, median age 55 [IQR 49-60], median MELD score 14 [IQR 11-17]). The most common cause of cirrhosis was alcohol (40%). The median pREE and mREE were 1652 (IQR 1459-1873) and 1708 (IQR 1490-1907) kcal/day, respectively. The mREE was lower in females and those with older age and malnutrition, significantly correlating with body composition measures (p < 0.01 for all). Most patients were normometabolic (88.6%), with others being hypometabolic (3.5%) or hypermetabolic (8.0%). After a median follow-up of 104 months (IQR 28-175), there were 107 LT and 49 deaths without LT. Hypermetabolism was independently associated with a worse LT-free survival (HR 2.11, 95%CI 1.161-3.845, p = 0.014) but, along with mREE, had no impact on post-LT graft survival.
Conclusions:
Patients with cirrhosis and hypermetabolism identified with IC had a two-fold increased risk of LT or death, independent of the MELD score and nutritional status. These findings suggest that IC provides valuable prognostic information for pre-LT assessment and may support individualized nutritional and risk stratification strategies in cirrhosis.
