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Exploring Vitamin D Trends Through Big Data Analysis.

Szilvia Racz1, Miklos Emri2, Ervin Berenyi2

  • 1Department of Medical Imaging, Faculty of Medicine, Kalman Laki Doctoral School of the University of Debrecen, University of Debrecen, 4032 Debrecen, Hungary.

Nutrients
|December 11, 2025
PubMed
Summary
This summary is machine-generated.

Big data analysis reveals vitamin D levels vary by age, sex, and season. Standardization of 25-hydroxyvitamin D (25(OH)D) testing methods is crucial for accurate vitamin D status assessment and public health.

Keywords:
25-hydroxyvitamin Dagebig datagendermethodologyseasonal variationsvitamin D

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Area of Science:

  • Medical Research
  • Biochemistry
  • Public Health

Background:

  • Vitamin D sufficiency knowledge is limited by small, short-term studies.
  • Big data analysis offers unprecedented insights into health characteristics.

Purpose of the Study:

  • To analyze vitamin D status trends using a large dataset.
  • To investigate factors influencing 25-hydroxyvitamin D (25(OH)D) concentrations.
  • To assess the impact of different testing methodologies.

Main Methods:

  • Utilized big data analytics on nearly 60,000 25-hydroxyvitamin D (25(OH)D) results from 2000 onwards.
  • Analyzed trends in test requests, seasonality, age, and sex differences.
  • Evaluated the influence of three distinct 25(OH)D determination methodologies.

Main Results:

  • Observed a significant increase in vitamin D testing requests from 2000 to 2020.
  • Noted a shift in the gender gap for test requests, with more men tested over time.
  • Identified clear demarcation of vitamin D insufficiency prevalence across demographics and seasons.
  • Detected statistically significant bias introduced by different 25(OH)D testing methodologies.

Conclusions:

  • Methodology significantly impacts 25-hydroxyvitamin D (25(OH)D) concentration results.
  • Urgent need for standardization of 25(OH)D measurement platforms.
  • Standardization is critical for accurate vitamin D status assessment and public health implications.