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Subjective cognitive complaints (SCC) predict dementia risk. Increasing participant concern over time significantly elevates this risk, highlighting the importance of longitudinal monitoring for early detection.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Subjective cognitive complaints (SCC) are key predictors of future dementia.
  • The SCD-plus framework highlights cognitive concern and informant corroboration.
  • Limited research has explored longitudinal changes in SCC concern.

Purpose of the Study:

  • To assess if baseline SCC concern and its longitudinal trajectories predict incident dementia over 10 years.
  • To differentiate the predictive value of participant versus informant reports of SCC concern.
  • To investigate the prognostic significance of evolving subjective cognitive experiences.

Main Methods:

  • Latent growth curve modeling analyzed SCC concern in 873 older adults (mean age 78.65).
  • Cox proportional hazards models examined dementia risk over 10 years.
  • Analyses controlled for demographic and clinical factors.

Main Results:

  • Baseline participant and informant SCC concern independently predicted dementia.
  • Increasing participant SCC concern over time significantly increased dementia risk (HR=10.23).
  • Changes in informant concern did not significantly alter dementia risk prediction.

Conclusions:

  • Participant and informant SCC concern offer distinct prognostic information for dementia risk.
  • Monitoring longitudinal changes in participant concern is crucial for dementia risk assessment.
  • Evolving subjective cognitive experiences may indicate underlying pathological changes, supporting clinical utility.