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Optimization of Poly(l-Amino Acids)-Based Platforms for Sensing and Biosensing: A Cyclic Voltammetry Study.
Giulia Selvolini1, Agnese Bellabarba2,3, Costanza Scopetani1
1Department of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, FI, Italy.
Sensors (Basel, Switzerland)
|December 11, 2025
Summary
This study optimized nanocomposite electrochemical platforms using poly(amino acids) and gold nanoparticles for sensing. These platforms show promise for developing sensitive electrochemical sensors and biosensors.
Area of Science:
- Electrochemistry
- Materials Science
- Nanotechnology
Background:
- Poly(amino acids) and gold nanoparticles offer biocompatibility and stability for sensing platforms.
- Nanocomposite electrochemical platforms combine these materials for enhanced performance.
Purpose of the Study:
- To optimize the fabrication of poly(amino acid)/gold nanoparticle nanocomposite platforms.
- To evaluate the performance of these platforms in electrochemical sensing applications.
Main Methods:
- Screen-printed graphite electrodes were modified via electropolymerization of l-amino acids.
- Gold nanoparticles were electrodeposited onto the modified electrodes.
- Cyclic voltammetry was used to optimize platform construction and analyze a model analyte.
Main Results:
- Optimized nanocomposite platforms were successfully fabricated.
- The electroactive surface area of the platforms was determined.
- Electrochemical oxidation of 1-naphthol was demonstrated, with peak current correlating to concentration.
Conclusions:
- The developed poly(amino acid)/gold nanoparticle platforms are effective for electrochemical sensing.
- These platforms show potential for the development of novel electrochemical sensors and biosensors.
