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Atypical Teratoid Rhabdoid Tumor: How Tumor Diagnostic Methods in the Laboratory Have Evolved over the Past 40 Years
Heather L Smith1, Pascale Aouad2, Nitin R Wadhwani3
1Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA.
Cancers
|December 11, 2025
Summary
Atypical Teratoid/Rhabdoid Tumor (AT/RT) is a rare CNS cancer. Advanced diagnostics like molecular profiling are crucial for accurate AT/RT classification and treatment, especially in challenging cases.
Area of Science:
- Neuro-oncology
- Molecular Pathology
- Pediatric Oncology
Background:
- Atypical Teratoid/Rhabdoid Tumor (AT/RT) is a highly aggressive central nervous system (CNS) neoplasm primarily affecting young children.
- AT/RT is defined by alterations in the SWI/SNF chromatin-remodeling complex, specifically involving SMARCB1 (INI-1) or SMARCA4 (BRG-1).
