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Related Experiment Video

Updated: Jun 21, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Published on: February 12, 2017

Rituximab-Induced Interstitial Lung Disease: A Possible Underestimated Complication-A Systematic Review.

Alexandra-Simona Zamfir¹, Mihai-Vasile Marinca^2,3, Carmen Lăcrămioara Zamfir⁴

¹Department of Medical Sciences III, Pulmonology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

|December 11, 2025

Summary

This summary is machine-generated.

Rituximab-induced interstitial lung disease (R-ILD) is a rare but serious complication. Early diagnosis and multidisciplinary management, often with corticosteroids, are crucial for patient outcomes.

Keywords:

B-cell lymphoproliferative disorders autoimmune conditions immunotherapy interstitial lung disease lung toxicity rituximab

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Published on: June 20, 2025

Area of Science:

Pulmonology
Immunology
Pharmacology

Background:

Rituximab, a CD20-targeting monoclonal antibody, has transformed B-cell disorder treatment.
Pulmonary adverse events, including rituximab-induced interstitial lung disease (R-ILD), are significant risks.
Diagnosing R-ILD is difficult due to non-specific symptoms and imaging.

Purpose of the Study:

To systematically review current evidence on R-ILD.
To analyze R-ILD incidence, diagnosis, management, and outcomes.
To synthesize data on R-ILD in patients receiving rituximab therapy.

Main Methods:

Systematic review of PubMed/MEDLINE literature up to August 2025.
Search term: "rituximab induced interstitial lung disease".
Analysis of 40 studies including case reports, series, and cohort studies.

Main Results:

R-ILD occurs in malignant and autoimmune conditions, often with combination regimens.
Radiological findings are diverse, with ground-glass opacities being common.
Most cases are reversible, but progression and fatal outcomes are possible; prophylactic trimethoprim-sulfamethoxazole may prevent pneumonitis.

Conclusions:

R-ILD is a rare but significant rituximab complication.
Early recognition and multidisciplinary care are vital.
Corticosteroids are effective, but severe cases may lead to respiratory failure or death.