Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply: Comment on "Prediction of clinically significant prostate cancer using extra-transitional zone prostate-specific antigen among Taiwanese men".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same author

Overweight status predicts improved overall survival after radical nephroureterectomy for upper tract urothelial carcinoma.

The Canadian journal of urology·2026
Same author

Factors Affecting Oncological Outcomes in Upper Tract Urothelial Carcinoma Patients with Chronic Kidney Disease and End-Stage Renal Disease.

Biomedicines·2026
Same author

Membrane-Anchored Serine Protease Inhibitors: Physiological Functions, Mechanisms, and Roles in Cancer.

International journal of molecular sciences·2026
Same author

Particulate matter 2.5 promotes bladder cancer cell migration and invasion through the crosstalk between integrin-mediated MAPK/ERK and Wnt/β-catenin pathways.

Particle and fibre toxicology·2026
Same author

High-CD14-expressing urothelial cancer cells foster a neutrophil-rich tumor microenvironment that increases the risk of radiation-promoted distant metastasis.

Journal of biomedical science·2026

Related Experiment Video

Updated: Jun 24, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.1K

Metabolomics-Based Liquid Biopsy for Predicting Clinically Significant Prostate Cancer.

Yuan-Chi Lin1, Chung-Hsin Chen2, Ming-Shyue Lee3

  • 1Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei 100225, Taiwan.

Cancers
|December 11, 2025
PubMed
Summary
This summary is machine-generated.

Metabolomics shows promise for detecting significant prostate cancer (PC) by analyzing blood and urine biomarkers. These novel metabolic panels may offer greater accuracy than prostate-specific antigen (PSA) testing.

Keywords:
Gleason scoreNational Comprehensive Cancer Network risk groupingclinically significant prostate cancermass spectrometrymetabolomicsnuclear magnetic resonance

More Related Videos

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.7K
A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
05:26

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

4.5K

Related Experiment Videos

Last Updated: Jun 24, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.1K
Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.7K
A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
05:26

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

4.5K

Area of Science:

  • Biochemistry
  • Oncology
  • Biomarker Discovery

Background:

  • Prostate cancer (PC) is a leading cause of cancer death in men.
  • Prostate-specific antigen (PSA) testing lacks specificity, leading to overdiagnosis and overtreatment of clinically insignificant PC (isPC).
  • Magnetic resonance imaging (MRI) aids detection but is costly and has limitations.

Purpose of the Study:

  • To review studies on blood and urine metabolomics for identifying biomarkers of significant PC (sPC).
  • To assess the potential of metabolomics as a tool for risk stratification in PC.
  • To compare the efficacy of metabolomic panels against traditional methods like PSA testing.

Main Methods:

  • Systematic review of studies investigating metabolomics in PC.
  • Analysis of metabolite changes in blood and urine samples from PC patients.
  • Evaluation of identified metabolic panels for sPC prediction accuracy.

Main Results:

  • Significant metabolite alterations in sPC involve fatty acid, sphingolipid, glycolysis, citric acid cycle, purine/pyrimidine, and tyrosine/phenylalanine metabolism.
  • Increased lactate and phenylalanine, decreased tyrosine, xanthine, and histidine levels were noted in sPC patients.
  • Metabolic panels, especially urine-based tests, demonstrated superior predictive performance compared to PSA, particularly when combined with clinical factors.

Conclusions:

  • Metabolomics-based liquid biopsies hold significant potential for improving sPC detection.
  • Standardization of protocols, integration with MRI, and validation in large cohorts are crucial for clinical translation.
  • Further research is needed to overcome methodological heterogeneity and enhance model credibility for widespread adoption.