Related Experiment Video
Updated: Jan 9, 2026

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
Three New Aporphine Alkaloids with Glucose Consumption Increase Activity from Cassytha filiformis
Caiyun Zhang1,2, Yongrui Lin2, Licui Xie2
1College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Abstract:
Aporphine alkaloids were the characteristic compounds with hypoglycemic effects in Cassytha filiformis. Utilizing chromatographic separation techniques including silica gel and semi-preparative high-performance liquid chromatography, three new aporphine alkaloids were successfully isolated and purified. Their structures were elucidated using various spectroscopic techniques, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy, as well as high-resolution electrospray ionization mass spectrometry (HRESIMS). The new compounds were identified as 10-demethylcassythine (1), 3-demethylcassythine (2), and N-demethyllastourvilline (3). The absolute configurations of the new compounds were determined using electronic circular dichroism (ECD) calculations. The effects of the new compounds on promoting glucose consumption in HepG2 cells at varying concentrations were tested. The results indicate that compound 1 significantly enhanced glucose consumption at 20 μM.
More Related Videos
08:07Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
Published on: August 24, 2016
07:05Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
Published on: September 10, 2018
Related Concept Videos
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Glycolysis: Preparatory Phase
Biosynthesis of Polysaccharides
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...