Reference Intervals for Hematological Inflammatory Ratios in Healthy Dogs.

Area of Science:

• Veterinary Hematology
• Biomarker Discovery
• Inflammatory Disease Research

Background:

• Hematological inflammatory ratios (neutrophil-to-lymphocyte, monocyte-to-lymphocyte, platelet-to-lymphocyte, systemic inflammatory index) show prognostic value in various diseases.
• These ratios are cost-effective and easily calculated biomarkers for early disease detection.

Purpose of the Study:

• To establish reference ranges for key hematological inflammatory ratios in the canine population.
• To provide essential data for supporting clinical veterinary practice and diagnostics.

Main Methods:

• Retrospective data collection from 156 healthy dogs with normal clinical and laboratory findings.
• Analysis of neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), and systemic inflammatory index (SII).
• Data stratified by sex and age groups (juvenile, adult, senior).

Main Results:

• Established reference intervals: NLR (1.3-7.1), MLR (0.1-0.3), PLR (40.4-271.1), SII (224.6-2191.7).
• Males exhibited significantly higher NLR than females.
• NLR differed significantly between juvenile and senior dogs.
• Senior dogs showed higher PLR and SII compared to adult and juvenile groups.

Conclusions:

• The study provides the first reference ranges for canine hematological inflammatory ratios.
• Sex and age significantly influence these inflammatory markers in dogs.
• These established ranges will aid veterinarians in interpreting hematological inflammatory ratios for improved canine health management.