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Can PRP Enhance Hamstring Recovery Post-ACL Reconstruction? Retrospective Insights from Non-Professional Athletes.

Roxana Mihaela Munteanu1,2,3, Andrei Marian Feier4,5, Bogdan Voicu2

  • 1Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.

Journal of Clinical Medicine
|December 11, 2025
PubMed
Summary
This summary is machine-generated.

Platelet-rich plasma (PRP) injections improved hamstring strength and symmetry after anterior cruciate ligament reconstruction (ACLR). This biologic adjunct enhanced recovery compared to rehabilitation alone, aiding a safer return to sport.

Keywords:
anterior cruciate ligament reconstructionhamstring recoverymuscle strengthplatelet-rich plasmarehabilitation

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Area of Science:

  • Orthopedics
  • Sports Medicine
  • Regenerative Medicine

Background:

  • Hamstring strength deficits and interlimb asymmetry are common post-ACLR, potentially increasing reinjury risk.
  • Standard rehabilitation may not fully restore hamstring function, highlighting the need for enhanced recovery strategies.
  • Platelet-rich plasma (PRP) shows promise as a biologic adjunct for improving tissue healing and muscle recovery.

Purpose of the Study:

  • To evaluate the efficacy of intra-articular PRP injections on hamstring strength restoration in non-professional athletes after ACL reconstruction (ACLR).

Main Methods:

  • Retrospective cohort study of 68 non-professional athletes undergoing primary ACLR.
  • Comparison between a PRP group (5 intra-articular injections) and a control group (rehabilitation alone).
  • Analysis using linear mixed-effects models to assess group, time, and interaction effects on hamstring strength and symmetry.

Main Results:

  • Both groups showed improvement, but the PRP group exhibited faster hamstring strength recovery and greater interlimb symmetry.
  • At 20 weeks, the PRP group had significantly higher concentric hamstring strength (p=0.040) and reduced asymmetry (p<0.001).

Conclusions:

  • Serial intra-articular PRP injections, when added to structured rehabilitation post-ACLR, accelerate hamstring strength recovery and improve interlimb symmetry.
  • PRP may be a valuable biologic adjunct for optimizing outcomes and facilitating a safer return to sport for athletes post-ACLR.