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Digital Workflow for Interim Prosthetic Rehabilitation Through the All-on-4 Concept Using 3D Printing Additive
Miguel de Araújo Nobre1, Ricardo Almeida2, Carlos Moura Guedes2
1Research, Development and Education, MALO CLINIC, Avenida dos Combatentes, 43, 1600-042 Lisbon, Portugal.
Journal of Clinical Medicine
|December 11, 2025
Summary
Fully digital workflows using 3D-printed prostheses with the All-on-4 concept show promising short-term success for full arch rehabilitation. This approach offers high patient satisfaction and good implant survival rates, validating its viability in implant dentistry.
Area of Science:
- Dentistry
- Biomaterials Science
- Digital Health
Background:
- The evolution of fully digital workflows in implant dentistry aims to enhance rehabilitation efficiency and patient satisfaction.
- Further scientific validation is required for these advanced digital protocols.
Purpose of the Study:
- To evaluate the 6-month outcomes of implant-supported fixed prostheses for full edentulism rehabilitation.
- To assess the efficacy of OnX Tough 2 resin and the Pro 2 3D printer within the All-on-4 concept.
Main Methods:
- The study included 16 patients receiving 20 implant-supported fixed full-arch prostheses using the All-on-4 concept.
- Both stackable guide and photogrammetry protocols were employed.
- Primary outcome: implant and prosthetic survival. Secondary outcomes: manufacturing issues, passive fit, marginal bone loss, complications, hygiene indexes, and patient-reported outcomes (OHIP-14).
Main Results:
- A 90% prosthesis survival and 97.5% implant survival rate at 6 months were observed.
- Mean marginal bone loss was 0.31 mm ± 0.52 mm at 4 months.
- High patient satisfaction reported for comfort (9.35/10) and chewing (8.79/10), with a low mean OHIP-14 score of 1.61.
Conclusions:
- Fully digital workflows utilizing 3D-printed prostheses with the All-on-4 concept are a viable short-term solution for full-arch rehabilitation.
- The study demonstrates favorable implant survival and high patient-reported outcomes.

