Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

486
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
486
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

752
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
752
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Free Open Access Medical Education (FOAM) in emergency medicine: use and perceived clinical relevance from a large cross-sectional survey.

International journal of emergency medicine·2026
Same author

Emergency training in medical practices and resuscitation quality: results from a regional study in Germany.

BMC emergency medicine·2026
Same author

On Superpowers, Oxytocin, and Sciences-Reflections on a Challenging Field.

Journal of integrative and complementary medicine·2026
Same author

Exploring the Role of Early Career Medical Professionals From a Digital-Oriented University in Germany in Promoting Digital Health in Professional Settings: Qualitative Interview Study.

JMIR medical education·2026
Same author

Measuring eHealth Literacy in the European Economic Area, Switzerland, and the United Kingdom: Scoping Review.

Journal of medical Internet research·2026
Same author

Social Transformation in Environmental Awareness: The Role of Hospital Employees in the Transformation Process-Results of a Survey in Germany.

Behavioral sciences (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 9, 2026

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

4.3K

Immersive, Open-World Virtual Reality for Dementia Care: NeuroVRX Pilot Study.

Martin Eckert1,2, Thomas Ostermann2, Jan Peter Ehlers2

  • 1Stabsstelle für Digitalisierung und Wissensmanagement, Hochschule Hamm-Lippstadt, 59063 Hamm, Germany.

Journal of Clinical Medicine
|December 11, 2025
PubMed
Summary
This summary is machine-generated.

This pilot study found that immersive, open-world virtual reality (VR) is a feasible, safe, and acceptable intervention for individuals with dementia. VR offers cognitive and motor stimulation, supporting its use in future therapeutic trials.

Keywords:
Alzheimer’s diseasecognitive impairmentdementiaexergamesmedicineopen-worldserious gamesvideo gamesvirtual reality

More Related Videos

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

19.0K
Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

4.5K

Related Experiment Videos

Last Updated: Jan 9, 2026

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

4.3K
Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

19.0K
Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

4.5K

Area of Science:

  • Gerontology
  • Neuroscience
  • Human-Computer Interaction

Background:

  • Alzheimer's disease and related dementias present growing global health and economic challenges.
  • Cognitive Stimulation Therapy (CST) offers non-pharmaceutical benefits for dementia patients.
  • Digital and virtual reality (VR) interventions for dementia, particularly in open-world environments, remain underexplored.

Purpose of the Study:

  • To assess the feasibility, acceptability, and safety of an immersive, open-world VR application for people diagnosed with dementia.
  • To explore the potential of VR as a tool for cognitive and motor stimulation in this population.

Main Methods:

  • A single-arm, unrandomised pilot study involving three male participants with dementia.
  • Participants engaged in a single VR session within an immersive, open-world environment, navigating freely via seated arm and head movements.
  • Data collected included session duration, virtual movement metrics, and participant feedback via questionnaires and anecdotal reports.

Main Results:

  • All participants completed the VR session without adverse events or cybersickness.
  • Average session time was 28 minutes, with participants virtually covering 0.9 km (1210 steps).
  • Questionnaires indicated positive usability and acceptance; anecdotal feedback highlighted immersion and autobiographical stimulation with minimal mood changes.

Conclusions:

  • Immersive, open-world VR is a feasible, safe, and well-accepted intervention for individuals with dementia.
  • The combination of advanced hardware and exploratory VR software provides cognitive and motor stimulation.
  • Results support the potential of 3D exploratory VR applications and warrant further controlled trials for therapeutic efficacy assessment.