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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

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Published on: April 13, 2015

The Relationship Between Laboratory Parameters and Coronary Slow Flow.

Muhammet Cakas¹, Hayrullah Yurdakul², Seda Elcim Yildirim³

¹Genc City Hospital, 12000 Bingol, Turkey.

Journal of Clinical Medicine

|December 11, 2025

Summary

Emergency department chest pain patients with coronary slow flow showed higher levels of C-reactive protein (CRP) and the CRP/albumin ratio. These inflammatory markers may help predict coronary slow flow in emergency settings.

Keywords:

chest pain coronary slow flow inflammation

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Area of Science:

Cardiology
Emergency Medicine
Clinical Biochemistry

Background:

Chest pain is a common emergency department (ED) presentation with diverse etiologies.
Coronary slow flow (CSF) is increasingly recognized as a clinical syndrome, not just an angiographic finding.
Identifying predictive laboratory markers for CSF in the ED is crucial for timely diagnosis and management.

Purpose of the Study:

To identify specific laboratory parameters that indicate coronary slow flow.
To evaluate the diagnostic utility of inflammatory markers in predicting CSF among patients presenting with chest pain.

Main Methods:

A case-control study involving 107 patients with primary coronary slow flow and 108 controls without cardiac pathology.
Patients presented to the ED with chest pain and underwent coronary angiography between 2019 and 2023.
Comparison of demographic, laboratory, clinical, and angiographic data between the CSF group and the control group.

Main Results:

Coronary artery dominance differed between groups, with Cx dominance in the CSF group and RCA dominance in controls (p < 0.001).
C-reactive protein (CRP) levels were significantly elevated in the CSF patient group (p < 0.001).
The CRP/albumin ratio was also significantly higher in patients with coronary slow flow (p < 0.001).

Conclusions:

Elevated levels of the inflammatory markers CRP and the CRP/albumin ratio are statistically significant in patients with coronary slow flow.
These laboratory parameters demonstrate potential as predictive tools for identifying coronary slow flow within the emergency department setting.