Related Experiment Video
Updated: Jan 9, 2026
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
The Relationship Between Laboratory Parameters and Coronary Slow Flow
Muhammet Cakas1, Hayrullah Yurdakul2, Seda Elcim Yildirim3
1Genc City Hospital, 12000 Bingol, Turkey.
Insights
Emergency department chest pain patients with coronary slow flow showed higher levels of C-reactive protein (CRP) and the CRP/albumin ratio. These inflammatory markers may help predict coronary slow flow in emergency settings.
Area of Science:
- Cardiology
- Emergency Medicine
- Clinical Biochemistry
Background:
- Chest pain is a common emergency department (ED) presentation with diverse etiologies.
- Coronary slow flow (CSF) is increasingly recognized as a clinical syndrome, not just an angiographic finding.
- Identifying predictive laboratory markers for CSF in the ED is crucial for timely diagnosis and management.
Purpose of the Study:
- To identify specific laboratory parameters that indicate coronary slow flow.
- To evaluate the diagnostic utility of inflammatory markers in predicting CSF among patients presenting with chest pain.
Main Methods:
- A case-control study involving 107 patients with primary coronary slow flow and 108 controls without cardiac pathology.
- Patients presented to the ED with chest pain and underwent coronary angiography between 2019 and 2023.
- Comparison of demographic, laboratory, clinical, and angiographic data between the CSF group and the control group.
Main Results:
- Coronary artery dominance differed between groups, with Cx dominance in the CSF group and RCA dominance in controls (p < 0.001).
- C-reactive protein (CRP) levels were significantly elevated in the CSF patient group (p < 0.001).
- The CRP/albumin ratio was also significantly higher in patients with coronary slow flow (p < 0.001).
Conclusions:
- Elevated levels of the inflammatory markers CRP and the CRP/albumin ratio are statistically significant in patients with coronary slow flow.
- These laboratory parameters demonstrate potential as predictive tools for identifying coronary slow flow within the emergency department setting.
Abstract:
Background/Objectives: One of the most prevalent reasons for attending the emergency department (ED) is chest pain. There are many causes of its etiology. Recent studies indicate that coronary slow flow should be considered not only an angiographic phenomenon but also a clinical syndrome. In our study, we aimed to identify laboratory parameters indicative of coronary slow flow. Methods: Patients who presented to the Emergency Department of Balikesir University Hospital with chest pain and underwent coronary angiography between 2019 and 2023 were evaluated. A group of 107 patients with primary coronary slow flow was included as the patient group, while 108 patients without any pathology were included as the control group. Demographic, laboratory, clinical, and angiographic parameters were compared between the two groups to determine the predictors of coronary slow flow. Results: In our study, RCA dominance was detected in the control group, while Cx dominance was detected in our patient group (p < 0.001). CRP and the CRP/albumin ratio were observed to be higher in the patient group (p < 0.001). Conclusions: The inflammatory markers CRP and CRP/albumin ratio were found to be statistically significantly higher in the patient group. These parameters can be used to predict coronary slow flow in the emergency department.
