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Etoricoxib-Induced Fixed Erythema.

Corina Porr1, Dana M Harris2, Anca Vidrighin3

  • 1Allergology Department, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania.

Journal of Clinical Medicine
|December 11, 2025
PubMed
Summary
This summary is machine-generated.

Fixed drug eruption (FDE) is a T cell-mediated reaction. This case highlights etoricoxib as a trigger and the importance of diagnostic testing for identifying safe alternatives in managing FDE.

Keywords:
cutaneous drug reactionetoricoxibfixed drug eruptionnon-steroidal anti-inflammatory drugsoral challenge testpatch test

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Area of Science:

  • Dermatology
  • Clinical Immunology

Background:

  • Fixed drug eruption (FDE) is a CD8+ T cell-mediated hypersensitivity.
  • Characterized by recurring plaques at the same site upon drug re-exposure.
  • Common triggers include NSAIDs and antibiotics; genetic factors like HLA alleles play a role.

Purpose of the Study:

  • To identify the causative agent of fixed drug eruption (FDE).
  • To confirm delayed-type hypersensitivity through diagnostic testing.
  • To evaluate potential safe therapeutic alternatives for FDE.

Main Methods:

  • Clinical evaluation including patch testing and oral drug provocation.
  • Assessment of alternative medications for FDE management.
  • Detailed patient history and physical examination.

Main Results:

  • A 53-year-old woman developed FDE after etoricoxib ingestion.
  • Oral challenge confirmed etoricoxib as the FDE trigger; patch testing was negative.
  • Celecoxib was identified as a potential safe alternative treatment.

Conclusions:

  • Accurate diagnosis of delayed cutaneous drug reactions requires an integrated approach.
  • Clinical assessment and confirmatory testing are crucial for FDE diagnosis.
  • Identifying safe therapeutic options is essential for patient management.