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Updated: Jun 12, 2026
Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Early Detection of Post-Traumatic Heterotopic Ossification in Bleeding Disorders Using Ultrasound: A Multi-Center
Bruno U K Steiner1,2, Mark A Krimmel1, Eric Chang3
1Clinical Research Division, Washington Center for Bleeding Disorders, Seattle, Washington, USA.
Abstract:
The post-traumatic formation of myotendinous heterotopic ossification or myositis ossificans traumatica has been an unforeseen complication of muscle contusion-related hematoma in people with hemophilia and von Willebrand's disease. While ultrasound imaging has revolutionized the detection of hemarthrosis and hemarthropathy in bleeding disorders, its clinical use has expanded to the detection of inter- and intramuscular hematomas, as well as the formation of traumatically induced heterotopic ossification. This retrospective multi-center case series includes 29 cases of post-traumatic heterotopic ossification from 9 hemophilia treatment centers, highlighting the effectiveness of high-definition point-of-care ultrasonography for its early detection in people with bleeding disorders.
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