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Updated: Jun 12, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Early Detection of Post-Traumatic Heterotopic Ossification in Bleeding Disorders Using Ultrasound: A Multi-Center
Bruno U K Steiner1,2, Mark A Krimmel1, Eric Chang3
1Clinical Research Division, Washington Center for Bleeding Disorders, Seattle, Washington, USA.
Post-traumatic heterotopic ossification is a complication in bleeding disorders. High-definition point-of-care ultrasonography effectively detects this condition early in patients with hemophilia and von Willebrand disease.
Area of Science:
- Orthopedics
- Radiology
- Hematology
Background:
- Myositis ossificans traumatica (heterotopic ossification) is an unforeseen complication of muscle contusions and hematomas.
- This condition is particularly noted in individuals with bleeding disorders like hemophilia and von Willebrand disease.
Purpose of the Study:
- To evaluate the effectiveness of high-definition point-of-care ultrasonography for early detection of post-traumatic heterotopic ossification.
- To highlight the utility of ultrasound in managing complications associated with bleeding disorders.
Main Methods:
- Retrospective multi-center case series.
- Inclusion of 29 cases of post-traumatic heterotopic ossification from 9 hemophilia treatment centers.
- Utilized high-definition point-of-care ultrasonography for diagnosis and assessment.
Main Results:
- High-definition point-of-care ultrasonography demonstrated effectiveness in detecting traumatically induced heterotopic ossification.
- Ultrasound imaging has expanded its role beyond hemarthrosis to include intramuscular hematomas and heterotopic ossification detection.
- Early detection was achieved in patients with bleeding disorders.
Conclusions:
- High-definition point-of-care ultrasonography is a valuable tool for the early detection of post-traumatic heterotopic ossification in individuals with bleeding disorders.
- Ultrasound imaging plays a crucial role in the comprehensive management of bleeding disorder complications.
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