Ivabradine Use for Arrhythmias in Children
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View abstract on PubMed
Summary
This summary is machine-generated.Ivabradine is a safe and effective treatment for pediatric arrhythmias, often used as a third-line therapy. This study evaluated its use in young patients, finding it well-tolerated with a high discharge rate.
Area Of Science
- Pediatric Cardiology
- Pharmacology
- Clinical Trials
Background
- Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated channel blocker.
- It is used off-label for treating arrhythmias in pediatric patients.
Purpose Of The Study
- To identify the line of therapy and arrhythmia type for initiating ivabradine in pediatric patients.
- To assess ivabradine dosing, tolerance in partially fed patients, home continuation rates, drug interactions, and adverse effects.
Main Methods
- Retrospective study of pediatric patients (<18 years) receiving ivabradine for arrhythmias from January 2021 to November 2023.
- Data collected included demographics, dosing, concomitant medications, feeding status, drug interactions, and adverse events like bradycardia and emesis.
Main Results
- Seventeen patients were included; atrial tachycardia was the most common indication.
- Ivabradine was typically a third-line therapy, with 58.8% initiated on partial enteral feeds.
- Median initial and peak doses were 0.05 and 0.07 mg/kg/dose, respectively; 94.1% had Class C drug-drug interactions.
- 58.8% were discharged home on ivabradine, with only one dose decrease due to adverse effects.
Conclusions
- Ivabradine demonstrated safety and efficacy as an add-on therapy for pediatric arrhythmias.
- Larger studies are warranted to further investigate ivabradine's role in pediatric arrhythmia management.
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