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The research progress of LACC1
Feng Li1,2, Xinyi Cui1,2, Qingli Yang1,2
1Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.
Abstract:
Laccase Domain-Containing 1(LACC1)is highly expressed in myeloid macrophages, and plays a crucial role in coordinating innate and adaptive immune responses by integrating lipid, polyamine, and purine metabolism pathways. This study comprehensively discusses the molecular structure, enzymatic functions, and signaling pathways associated with LACC1. Notably, the M-CSF/AKT/mTOR/LACC1 pathway primarily regulates cellular autophagy. Additionally, the PPARα/RXR/PPRE/LACC1, miR-211-5p/KDM2B/LACC1, LACC1/AMPK/NLRP3, LACC1/NF-kB, LACC1/MAPK, LACC1/ROS/NOD2/PIPK2, LACC1/JAK-STAT, and LACC1/CCL5 signaling pathways are significantly involved in modulating inflammatory responses. Furthermore, the article provides a comprehensive summary of the pathogenic mechanisms and recent advancements in research concerning LACC1 in immune diseases, metabolic disorders, infectious diseases, and neurological conditions. In conclusion, LACC1 serves as a pivotal immune-metabolic hub, offering new insights and potential therapeutic targets for the study of related diseases.
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