The research progress of LACC1.

Area of Science:

• Immunology
• Metabolism
• Molecular Biology

Background:

• Laccase Domain-Containing 1 (LACC1) is highly expressed in myeloid macrophages.
• LACC1 integrates lipid, polyamine, and purine metabolism, coordinating immune responses.

Purpose of the Study:

• To comprehensively discuss the molecular structure, enzymatic functions, and signaling pathways of LACC1.
• To summarize pathogenic mechanisms and research advancements of LACC1 in various diseases.

Main Methods:

• Literature review and pathway analysis.
• Comprehensive discussion of LACC1's role in cellular processes and disease.

Main Results:

• The M-CSF/AKT/mTOR/LACC1 pathway regulates autophagy.
• Multiple signaling pathways (e.g., PPARα, miR-211-5p, AMPK, NF-kB, MAPK, ROS, JAK-STAT, CCL5) are involved in LACC1-mediated inflammation.
• LACC1 is implicated in immune diseases, metabolic disorders, infectious diseases, and neurological conditions.

Conclusions:

• LACC1 acts as a pivotal immune-metabolic hub.
• LACC1 provides novel insights and potential therapeutic targets for related diseases.