Related Experiment Video
Updated: Jan 9, 2026
Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
Published on: May 25, 2022
Conjugated Hyperbilirubinemia in a Patient With COVID-19: A Case Report and Literature Review
Haider Ghazanfar1, Faryal Altaf1, Ali Ghazanfar2
1Internal Medicine, BronxCare Health System, Bronx, USA.
Insights
This case report details a patient with COVID-19 who developed jaundice and conjugated hyperbilirubinemia. Treatment for coronavirus disease 2019 led to the improvement of hyperbilirubinemia, suggesting a potential link.
Area of Science:
- Internal Medicine
- Infectious Diseases
- Gastroenterology
Background:
- Coronavirus disease 2019 (COVID-19) presents with diverse clinical manifestations.
- Hyperbilirubinemia is a significant clinical finding that requires thorough investigation.
- The association between COVID-19 and hyperbilirubinemia is not fully understood.
Abstract:
Coronavirus disease 2019 (COVID-19) was first reported at the end of 2019 and soon evolved into a deadly pandemic of the century. It has a myriad of clinical presentations and is associated with significant mortality and morbidity. We report a case of a 49-year-old Hispanic man who presented to the emergency department with complaints of productive cough, shortness of breath, fever, and body aches for the past five days. On clinical examination, he was noted to have jaundice. Laboratory results revealed conjugated hyperbilirubinemia and elevated alkaline phosphatase. The patient tested positive for COVID-19 and appropriate treatment was initiated as per hospital protocols. All potential causes of hyperbilirubinemia were systematically excluded, including autoimmune, metabolic, hemolytic, septic, drug-induced, parasitic, and biliary etiologies. Hyperbilirubinemia improved with the treatment of COVID-19. All other causes of hyperbilirubinemia must be excluded in these individuals before attributing it to COVID-19. Further research is needed to understand the disease and to guide appropriate therapy.
Related Concept Videos
02:50Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
01:26Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:21Hepatic Portal System
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...