Congenital Infantile Fibrosarcoma of the Ileum in a 4-Day-Old Female Neonate Mimicking Intestinal Atresia: A Rare

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Nooshin Zaresharifi1, Azadeh Jafari2, Anita Khalili3

  • 1Neuroscience Research Center, School of Medicine Guilan University of Medical Sciences Rasht Iran.

Clinical Case Reports
|December 11, 2025
PubMed

Insights

Congenital infantile fibrosarcoma (CIFS) is a rare cause of neonatal intestinal obstruction. Early consideration of CIFS in infant intestinal masses is crucial for accurate diagnosis and management.

Area of Science:

  • Pediatric Surgery
  • Neonatal Pathology
  • Oncology

Background:

  • Congenital infantile fibrosarcoma (CIFS) is an uncommon tumor presenting in neonates.
  • CIFS can manifest as neonatal intestinal obstruction, mimicking intestinal atresia.
  • Accurate differentiation is vital for appropriate therapeutic strategies.

Purpose of the Study:

  • To highlight congenital infantile fibrosarcoma as a differential diagnosis for neonatal intestinal obstruction.
  • To emphasize the importance of histopathological and immunohistochemical analyses in diagnosing CIFS.
  • To guide the management of infants presenting with intestinal masses.

Main Methods:

  • Case report presentation.
  • Review of relevant literature.
  • Discussion of diagnostic modalities including histopathology and immunohistochemistry.

Main Results:

  • Congenital infantile fibrosarcoma presents a diagnostic challenge due to its mimicry of intestinal atresia.
  • Comprehensive histopathological and immunohistochemical evaluations are essential for definitive diagnosis.
  • Timely diagnosis facilitates appropriate surgical and medical management.

Conclusions:

  • Congenital infantile fibrosarcoma should be included in the differential diagnosis of neonatal intestinal obstruction.
  • Accurate diagnosis of CIFS relies on detailed pathological examination.
  • Appropriate management strategies are guided by a confirmed CIFS diagnosis.

Keywords:
congenital infantile fibrosarcomagastrointestinal infantile fibrosarcomainfantile fibrosarcomaintestinal massintestinal neoplasms

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