Related Experiment Video
Updated: Jan 9, 2026
Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
Evaluation of Progel in minimally invasive segmentectomy: a multicentric retrospective series
Giulia Fabbri1,2, Nabih Berjaoui1, Akshay Patel1
1Thoracic Surgery Department, Guy's Hospital, Guy's and St Thomas NHS Foundation Trust, London, UK.
Background:
In the past years, segmentectomy has been increasingly used to remove small peripheral lung cancers; however, segmentectomies seem to be associated with an increased incidence of prolonged air-leaks compared to lobectomies. Over the years, numerous air sealants were tested, but the most effective of all appears to be ProgelTM Platinum. Although this sealant has been proved to be effective in reducing post-operative air-leaks in lobectomies, there are still little data about its efficacy in segmentectomies. Our aim is to evaluate the safety and effectiveness of ProgelTM Platinum for intraoperative closure of air leaks during pulmonary segmentectomy.
Methods:
Retrospective comparative cohort study of consecutive patients undergone anatomical segmentectomy at two high-volume centres between January 2018 and September 2022. Patients were divided in two groups according to whether the sealant was used. The sealant was applied intraoperatively to the remaining lung. Prolonged air leak (PAL) was defined as lasting more than 5 days.
Results:
One hundred and eighty-one patients were included in the study: 90 patients in the sealant group (SG) and 91 in the control group (CG). PAL was observed in 5.5% (n=5) of patients in the SG compared to 12.1% (n=11) in the CG (P=0.19). In the CG, there was a significant difference in the rate of PAL following a simple and complex segmentectomy (2.8% vs. 18.2%; P=0.03), while in the SG, the rate of PAL did not differ between the two (6.1% vs. 5.3%; P=0.87). The mean duration of chest tubes was significantly lower in the SG compared to the CG vs. 3.8±4.8 days, P=0.02). The mean length of hospitalization was 4±2.8 days in the SG vs. 7±5.0 days in the CG (P<0.001). The sealant was not associated with any adverse events.
Conclusions:
The sealant was safe and effective for intraoperative closure of air leaks following segmentectomy. Use of the sealant decreased the rate of PALs and it led to a significant reduction in chest tube duration and length of hospitalization.
