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Magnetic Resonance Imaging, Fluorescence, and Drug Release Properties of Curcumin-Loaded PEGylated Magnetite@Graphene
Baharak Divband1,2,3, Amal Y Al-Yasiri4, Najwan Mohammed Saeed4
1Medical Radiation Sciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background:
Multifunctional nanosystems, containing medical imaging components and cancer therapeutic drugs, can provide early cancer diagnosis and treatment.
Objective:
The aim of this study was to investigate Magnetic Resonance Imaging (MRI), anticancer drug delivery, and fluorescence properties of curcumin-loaded PEGylated magnetite@graphene quantum dots nanocomposite.
Material And Methods:
In this experimental study, PEGylated magnetite@graphene quantum dots (Fe3O4@GQDs-PEG) nanocomposite was synthesized and loaded with curcumin (CUR-Fe3O4@GQDs-PEG). Then, the size, shape, magnetic property, MRI r2 relaxivity, drug loading and in vitro release, and fluorescence property of the nanocomposite were investigated. Evaluation of the cell toxicity against MCF-7 cells was performed for both unloaded and curcumin-loaded nanocomposites.
Results:
The superparamagnetic nanocomposite showed high r2 relaxivity, drug release, and fluorescence property. The curcumin-loaded nanocomposite was significantly toxic to the breast cancer cell line at high concentrations.
Conclusion:
CUR-Fe3O4@GQDs-PEG nanocomposite can be considered an anticancer drug carrier and an appropriate potential candidate for dual modal MRI and fluorescence imaging.
