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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
Regulated cell death in age-related macular degeneration: Regulatory mechanisms and therapeutic potential
Le-Le Zhang1, Jia-Mei Yu2, Zhong-Xi Fan3
1School of Basic Medical Sciences, Chengdu University, Chengdu, 610106, China.
Abstract:
Age-related macular degeneration (AMD) represents a predominant cause of blindness among older adults, with limited therapeutic options currently available. Oxidative stress, inflammation, and retinal pigment epithelium injury are recognized as key contributors to the pathogenesis of AMD. Regulated cell death plays a pivotal role in mediating cellular responses to stress, maintaining tissue homeostasis, and contributing to disease progression. Recent research has elucidated several regulated cell death pathways-such as apoptosis, ferroptosis, pyroptosis, necroptosis, and autophagy-that may contribute to the progression of AMD owing to cell death in the retinal pigment epithelium. These discoveries open new avenues for therapeutic interventions in patients with AMD. In this review, we provide a comprehensive summary and analysis of the latest advancements regarding the relationship between regulated cell death and AMD. Moreover, we examined the therapeutic potential of targeting regulated cell death pathways for the treatment and prevention of AMD, highlighting their roles as promising targets for future therapeutic strategies.
Insights
Regulated cell death pathways contribute to age-related macular degeneration (AMD) progression. Targeting these pathways offers new therapeutic strategies for AMD treatment and prevention.
Area of Science:
- Ophthalmology
- Cell Biology
- Pathogenesis of Age-related Macular Degeneration
Background:
- Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults.
- Oxidative stress, inflammation, and retinal pigment epithelium injury are key factors in AMD pathogenesis.
- Regulated cell death pathways are crucial in cellular responses to stress and disease progression.
Purpose of the Study:
- To review and analyze the relationship between regulated cell death and AMD.
- To examine the therapeutic potential of targeting regulated cell death pathways for AMD.
- To highlight promising future therapeutic strategies for AMD treatment and prevention.
Main Methods:
- Comprehensive literature review of recent advancements.
- Analysis of the role of various regulated cell death pathways (apoptosis, ferroptosis, pyroptosis, necroptosis, autophagy) in AMD.
- Evaluation of therapeutic strategies targeting these pathways.
Main Results:
- Several regulated cell death pathways are implicated in the progression of AMD through retinal pigment epithelium cell death.
- Understanding these pathways opens new avenues for therapeutic interventions.
- Targeting specific cell death mechanisms shows promise for AMD treatment.
Conclusions:
- Regulated cell death pathways are significant contributors to AMD pathogenesis.
- Targeting these pathways represents a promising therapeutic avenue for AMD.
- Further research into these pathways could lead to novel prevention and treatment strategies for AMD.
