Related Experiment Video
Updated: Jan 9, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Diabetes-specific oral nutritional supplement for prediabetes improves postprandial glycemic responses: an
Yeongtaek Hwang1,2, Minkyung Bok1,2, Suk Chon3
1Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea.
Background/Objectives:
Regulating the postprandial glucose levels is crucial for preventing the progression of prediabetes to diabetes. This study examined the effects of a diabetes-specific nutrition formula (DSNF) on the postprandial plasma glucose, serum insulin, and serum c-peptide levels in individuals with prediabetes.
Subjects/Methods:
An open-label, crossover clinical trial was conducted to compare the effects of the DSNF versus standard oral nutritional supplement (ONS) on glycemic control. Fifteen subjects with prediabetes were enrolled and received the DSNF on the first visit and standard ONS on the second. The postprandial plasma glucose, serum insulin, and serum c-peptide incremental area under the curve (iAUC), as well as the incremental maximal concentration (iCmax) and the maximum concentration (Cmax), were measured after each intervention. Statistical comparisons between DSNF and standard ONS were conducted using a Wilcoxon's signed-rank test.
Results:
After consuming the DSNF, the iAUC of the postprandial glucose level was significantly low compared to the standard ONS (1,683.49 ± 911.65 vs. 4,455.92 ± 1,658.77, P < 0.0001). Similarly, the serum insulin iAUC (2,017.33 ± 987.64 vs. 2,570.59 ± 1,201.09, P = 0.0181) and c-peptide iAUC (274.17 ± 116.12 vs. 491.18 ± 123.90, P < 0.0001) decreased significantly after DSNF administration compared to the standard ONS.
Conclusions:
The consumption of DSNF significantly improved the postprandial glucose, insulin, and c-peptide responses compared to the standard ONS.
Trial Registration:
Clinical Research Information Service Identifier: KCT0008904.
More Related Videos
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
Related Concept Videos
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Type 2 and Gestational
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...