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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
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Unexpected complete resolution of intravesical inflammatory myofibroblastic tumor after immunotherapy for melanoma: A

Michael Lesgart1, Steven Leonard1, Francesca Montanaro1

  • 1The Urologic Institute, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.

Urology Case Reports
|December 11, 2025
PubMed

Inflammatory myofibroblastic tumors (IMT) are exceedingly rare, particularly when originating in the bladder. Complete surgical resection is the gold standard treatment for IMTs. We describe a case of IMT of the urinary bladder that achieved complete radiographic and endoscopic resolution after systemic treatment with ipilimumab and nivolumab directed towards metastatic melanoma. This case is noteworthy due to the tumor's serendipitous and remarkable response to immunotherapy.

Keywords:
ImmunotherapyInflammatory myofibroblastic tumorMelanomaTransurethral resection

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