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Circulating microRNA-219 in stroke: Lack associations with clinical parameters and post-stroke epilepsy risk
Zeynab Fahimi1, Mohammad Kazemi2,3, Habibollah Rahimi4
1Department of Neurology, Kashan University of Medical Sciences, Kashan, Iran.
IBRO Neuroscience Reports
|December 11, 2025
Summary
Circulating microRNA-219 (miR-219) is elevated in stroke patients but does not predict post-stroke epilepsy (PSE). Further research with larger cohorts is needed to confirm these findings on miR-219
Area of Science:
- Biomarkers
- Neuroscience
- Genetics
Background:
- Post-stroke epilepsy (PSE) is a common complication in stroke survivors.
- Early diagnostic biomarkers for PSE are currently lacking.
- Investigating circulating microRNA-219 (miR-219) as a potential early biomarker for PSE.
Purpose of the Study:
- To determine if circulating miR-219 can serve as a reliable biomarker for the early detection of post-stroke epilepsy (PSE).
Main Methods:
- Serum samples were collected from 40 stroke patients and 20 healthy controls.
- Circulating miR-219 levels were measured using real-time PCR.
- Predictive performance was evaluated using ROC analysis, comparing miR-219 and the PoSERS model.
Main Results:
- Circulating miR-219 was significantly elevated in stroke patients compared to controls.
- No significant difference in miR-219 levels was found between patients with and without PSE.
- MiR-219 showed no predictive value for PSE (AUC=0.49), while the PoSERS model demonstrated predictive value (AUC=0.72).
Conclusions:
- Circulating miR-219 is not a suitable biomarker for predicting PSE development.
- Larger sample sizes are required to validate these findings and explore the predictive potential of miR-219.
