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Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes -

Klaudia Bogusz-Górna1, Adriana Polańska2, Aleksandra Dańczak-Pazdrowska2

  • 1Department of Pediatric Diabetes, Auxology, and Obesity, Poznan University of Medical Sciences, Poznan, Poland.

Frontiers in Endocrinology
|December 11, 2025
PubMed

Insights

Children with type 1 diabetes show impaired epidermal barrier function, with higher transepidermal water loss (TEWL) and reduced skin hydration linked to poor metabolic control. These noninvasive tests can identify at-risk individuals.

Area of Science:

  • Pediatrics
  • Dermatology
  • Endocrinology

Background:

  • Epidermal barrier function in children with type 1 diabetes is understudied.
  • Previous research has not focused on transepidermal water loss (TEWL) and epidermal hydration in this population.

Purpose of the Study:

  • To evaluate epidermal barrier function in children and adolescents with type 1 diabetes.
  • To assess transepidermal water loss (TEWL) and epidermal hydration in pediatric patients with type 1 diabetes.

Main Methods:

  • Included 125 children and adolescents with type 1 diabetes and 35 healthy controls (aged 6-18).
  • Utilized clinical evaluation, transepidermal water loss (TEWL) measurement, and epidermal hydration (corneometry).

Main Results:

  • Poor metabolic control (higher HbA1c, hyperglycemia) negatively impacts TEWL and epidermal hydration.
  • Blood flow (BF%) positively correlated with TEWL.

Conclusions:

  • TEWL and corneometry are valuable supplementary tests for periodic examinations in children with type 1 diabetes.
  • Monitoring skin hydration and TEWL can help identify patients at risk for diabetic neuropathy and foot complications.
Abstract

Keywords:
TEWLadolescentschildrencorneometryepidermal barrierepidermis hydrationtransepidermal water losstype 1 diabetes

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