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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
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Targeted nanoliposomal nutrient delivery for human health.

Joseph Mercola1

  • 1Midwestern University, Downers Grove, IL 60515, United States. drm@mercola.com.

World Journal of Gastrointestinal Pharmacology and Therapeutics
|December 11, 2025
PubMed
Summary

Nanoliposomal delivery enhances nutrient stability and absorption, improving targeted delivery to organs like the kidney and mitochondria. Overcoming manufacturing and cost challenges is key to translating nanonutrient technology for better health outcomes.

Keywords:
Coenzyme Q10Endosomal escapeMitochondrial targetingNanoliposomal deliveryNutrient bioavailabilityOral lymphatic transportPolyethylene glycol limitationsPrecision nutritionReceptor mediated endocytosisTargeted supplementation

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Area of Science:

  • Biomaterials Science
  • Nutraceuticals
  • Drug Delivery Systems

Background:

  • Conventional nutritional supplements have limited efficacy due to gastrointestinal degradation, poor absorption, and rapid clearance.
  • Nanoliposomal delivery platforms offer a strategy to protect nutrients and enhance targeted delivery.
  • A comprehensive review of nanoliposomal nutrient carriers is needed to guide innovation.

Purpose of the Study:

  • To summarize the physicochemical basis of nanoliposomal nutrient carriers.
  • To review organ- and organelle-specific targeting strategies, focusing on renal and mitochondrial delivery.
  • To evaluate therapeutic evidence for cardiometabolic, neuroprotective, and renal repair applications and identify translational challenges.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, and Scopus (up to May 2025) using keywords: nanoliposome, nutrient, targeted delivery, bioavailability, kidney, mitochondria.
  • Inclusion of primary research articles, systematic reviews, and meta-analyses.
  • Data extraction on liposomal composition, modifications, bio-distribution, efficacy, and safety.

Main Results:

  • Nanoliposomes enhanced nutrient stability and improved trans-epithelial transport (2-10 fold).
  • Ligand-mediated targeting increased renal uptake (up to 4 fold); mitochondrial targeting restored membrane potential and reduced ROS in preclinical models.
  • PEGylation improved circulation but caused immunogenicity; alternative coatings show promise. Scalability and GMP-compliant manufacturing remain limited.

Conclusions:

  • Targeted nanoliposomal systems significantly improve nutrient stability, absorption, and tissue specificity, offering potential for cardiometabolic, renal, and neuroprotective therapies.
  • Optimization of lipid composition, escape mechanisms, and surface chemistries can enhance therapeutic effects.
  • Industrial-scale manufacturing, cost reduction, and immunogenicity management are critical hurdles for clinical translation.