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Updated: Jan 9, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

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Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma

Enrique Oropeza-Martínez1, Eva G Palacios Serrato1, Sayra X Zamora-Salas1

  • 1Posgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico.

World Journal of Biological Chemistry
|December 11, 2025
PubMed

Insights

Interferon gamma (IFN-γ) signaling is altered in glioblastoma, promoting tumor growth through specific interferon-stimulated genes (ISGs). Targeting these ISGs offers potential therapeutic strategies for this aggressive brain cancer.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Interferon gamma (IFN-γ) signaling via the JAK/STAT pathway regulates gene expression.
  • In glioblastoma, this signaling pathway is deregulated, leading to overexpression of STAT1-target interferon-stimulated genes (ISGs).
  • These ISGs are implicated in glioblastoma progression.

Purpose of the Study:

  • To review key ISGs involved in glioblastoma pathology.
  • To highlight the role of IFN-γ signaling in glioblastoma.
  • To discuss the potential of ISGs as biomarkers and therapeutic targets.

Main Methods:

  • Literature review of ISGs in glioblastoma.
  • Analysis of IFN-γ canonical signaling pathways.
  • Identification of STAT1-target ISGs.

Main Results:

  • STAT1 and other ISGs (IRF1, PD-L1, IDO1, ISG15) are overexpressed in glioblastoma.
  • These genes contribute to tumor progression.
  • IFN-γ signaling deregulation is a key feature of glioblastoma.

Conclusions:

  • STAT1-target ISGs are critical in glioblastoma pathogenesis.
  • These genes represent potential biomarkers for glioblastoma.
  • Targeting IFN-γ signaling and its downstream ISGs may offer new therapeutic avenues for glioblastoma.
Keywords:
B7-H1 antigenGlioblastomaIndoleamine-2,3-dioxygenaseInterferon gammaInterferon regulatory factor 1Interferon-stimulated gene 15Interferon-stimulated genesJanus kinasesSignal transducer and activator of transcription 1Signal transduction

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