Related Experiment Video

Updated: Jan 7, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

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Advancing depression treatment: the role of sigma receptor ligands

Peng Zhang1,2, Zeqiong Ning3, Haixia Chen1

  • 1Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Key Laboratory of Anesthesiology (The Fourth Military Medical University), Ministry of Education, Shaanxi Provincial Clinical Research Center for Anesthesiology Medicine, Xi'an, China.

Frontiers in Neuroscience
|December 11, 2025
PubMed

Keywords:
Ca2+ responsesdepressionglutamatergic dysfunctionneuroinflammationneuronal plasticityserotonergic systemsigma receptorsigma receptor ligands

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