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Related Experiment Video

Updated: Jan 9, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
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Predicting Early Dysphagia in Acute Ischemic Stroke Using an Explainable Machine Learning Model.

Ye Li1,2, Sihao Yu3, Xiaojuan Yu4

  • 1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

International Journal of General Medicine
|December 11, 2025
PubMed
Summary
This summary is machine-generated.

Machine learning accurately predicts early dysphagia in acute ischemic stroke (AIS) patients. The Random Forest model identified key risk factors like ADL grade and NIHSS score, aiding early intervention.

Keywords:
dysphagiaischemic strokemachine learningpredictive modelrisk factors

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Area of Science:

  • Neurology
  • Medical Informatics
  • Machine Learning

Background:

  • Dysphagia is a common complication following acute ischemic stroke (AIS).
  • Early detection of dysphagia is crucial for patient outcomes and preventing complications.
  • Predictive models can aid clinicians in identifying at-risk patients.

Purpose of the Study:

  • To identify key risk factors for early dysphagia in AIS patients.
  • To develop an explainable machine learning (ML) model for dysphagia prediction.
  • To evaluate the performance of various ML models in predicting dysphagia.

Main Methods:

  • A cross-sectional study included 1041 AIS patients.
  • Feature selection used Boruta algorithm and logistic regression.
  • Six ML models were trained and evaluated using 10-fold cross-validation, with performance metrics including AUC-ROC, sensitivity, and specificity.

Main Results:

  • The incidence of early dysphagia in AIS patients was 29.3%.
  • The Random Forest (RF) model achieved the highest performance (AUC-ROC: 0.952).
  • Significant predictors included ADL grade, NIHSS score, multifocal lesions, hypoalbuminemia, coronary heart disease, and lesion hemisphere.

Conclusions:

  • ML models, particularly the RF model, show promise as reliable tools for predicting dysphagia in AIS.
  • The developed model can assist clinicians in early risk assessment and personalized treatment planning.
  • Explainable AI (SHAP analysis) provides insights into the identified risk factors.