Adjudicated Cardiovascular Events in Patients With COVID-19: Association With Vaccination Status and Changes over...

Area of Science:

• Cardiology
• Infectious Diseases
• Epidemiology

Background:

• Patients with COVID-19 are susceptible to thrombotic and cardiovascular complications.
• Previous risk estimates may not reflect current event rates or vaccination impacts.
• Understanding contemporary trends and vaccination effects is crucial for patient management.

Purpose of the Study:

• To assess recent rates of thrombotic and cardiovascular events in COVID-19 patients.
• To analyze temporal trends in these events over time.
• To determine the association between COVID-19 vaccination status and cardiovascular outcomes.

Main Methods:

• Utilized the CORONA-VTE Network multicenter registry (March 2020-February 2024).
• Assessed composite outcomes of thrombotic and cardiovascular events at 90 days post-COVID-19 diagnosis.
• Conducted time-to-event analyses stratified by inpatient/outpatient status, adjusting for competing risks.

Main Results:

• Among 11,165 patients, 4,451 were inpatients with 90-day incidences of 8.9% for thrombotic and 15.6% for cardiovascular events.
• Intensive care unit patients had higher event rates (20.0% thrombotic, 30.7% cardiovascular).
• COVID-19 vaccination was associated with a reduced risk of cardiovascular events (adjusted HR, 0.75; P=0.005).

Conclusions:

• Thrombotic and cardiovascular events remain common in hospitalized COVID-19 patients, especially in the ICU.
• No persistent decline in cardiovascular events was observed over the study period.
• COVID-19 vaccination demonstrated a protective association against cardiovascular events.