A Web-Based Calculator for Hematopoietic Progenitor Cell Collections: App Development and Retrospective Assessment

A major challenge in hematopoietic progenitor cell apheresis is determining the whole blood (WB) volume to process to achieve a CD34+ cell collection goal. We developed a web-based calculator app that uses the Collection Efficiency 2 (CE2) model to estimate personalized WB processing volumes needed to reach a prescribed CD34+ cell collection goal. Retrospective evaluation of the app using collection data from two academic medical centers showed that actual processed WB volumes were frequently higher than the app's recommendations. The frequency of potential under-collection events is predicted to be low had the app-calculated volumes been utilized. Our findings suggest that using the app's recommendations may lower total WB processing volumes, reducing over-collection and time spent on the apheresis machine, while maintaining a low under-collection risk profile.