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Updated: Jan 8, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
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Severity of liver disease is associated with cirrhotic cardiomyopathy: A multicenter study

Xiaohan Ying1, Adesola O Oje2, Anton J De Witte3

  • 1Weill Cornell Medicine, Division of Gastroenterology and Hepatology, New York, New York, USA.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
|December 11, 2025
PubMed

Insights

Cirrhotic cardiomyopathy (CCM) is linked to liver disease severity in cirrhosis patients awaiting liver transplant. Early detection of CCM is crucial for managing liver disease complications.

Area of Science:

  • Cardiology
  • Hepatology
  • Transplant Medicine

Background:

  • Cirrhotic cardiomyopathy (CCM) is subclinical cardiac dysfunction in cirrhosis patients.
  • CCM may exacerbate cirrhosis complications like Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI).
  • The association between liver disease severity and CCM features requires further characterization.

Purpose of the Study:

  • To investigate the association between liver disease severity and the presence of CCM.
  • To identify factors associated with CCM and its echocardiographic features in cirrhosis patients.
  • To explore the relationship between CCM and HRS-AKI in this population.

Main Methods:

  • Retrospective study of adult cirrhosis patients undergoing liver transplant (LT) between 2015-2018.
  • Analysis of pre-LT echocardiographic studies to identify CCM markers.
  • Multivariable models assessed associations between liver disease severity indices (CTP, MELDNa), comorbidities, and CCM presence/features.

Main Results:

  • CCM was present in 23% of patients.
  • Moderate to severe ascites and higher MELDNa scores were associated with CCM presence.
  • Liver disease severity (MELDNa, CTP) correlated with specific echocardiographic CCM features.
  • CCM was not independently associated with HRS-AKI, though severe liver disease was.

Conclusions:

  • Liver disease severity is positively associated with CCM presence and echocardiographic features in LT candidates.
  • Findings may aid in patient selection and promote early CCM detection in cirrhosis.
  • Further research into CCM's role in cirrhosis complications is warranted.

Keywords:
cirrhotic cardiomyopathyliver transplantation

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